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#Allergy and Immunology #Pediatrics
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A new study published in Current Opinion in Pediatrics aimed to determine various associations of the human microbiome with allergic disease and effective therapeutic interventions to prevent allergy. From the findings, it was concluded that the microbiota is influenced by multiple factors, including the mode of infant delivery (vaginal versus cesarean section), breastfeeding, diet, presence of siblings and pets, exposure to antibiotics and other medications (particularly antacids), lifestyle and developmental context. The authors speculated that specific microbiota act through distinct metabolic pathways to promote the health of their human hosts, optimally directing the developing immune system away from pro-allergic, Th2-dominated responses to more T-regulatory-influenced behaviors. In inference, it was stated that specific healthy infant microbiome signatures may influence the development of some components of the allergic march of childhood by decreasing atopic dermatitis, asthma and food allergy.