EXPLORE!

Towards antibiotic stewardship: Reducing antibiotic duration

  819 Views

Dr KK Aggarwal    10 February 2019

7 days non-inferior to 14 days of antibiotic therapy for uncomplicated Gram-negative bacteremia

 

In patients hospitalized with uncomplicated Gram-negative bacteremia, an antibiotic course of 7 days was non-inferior to 14 days, according to a randomized, multicenter trial published in Clinical Infectious Diseases, an official journal of the Infectious Diseases Society of America (IDSA).

 

The study conducted in three centers in Israel and Italy examined 604 hospitalized patients with uncomplicated i.e. afebrile and hemodynamically stable for at least 48 hours, gram-negative bacteremia (mostly Enterobacteriaceae). The patients were randomized to antibiotic treatment for 7 days and 14 days.

 

The primary outcome - composite of all-cause mortality; relapse, suppurative or distant complications and re-admission or extended hospitalization (>14 days) – rates were comparable in the two groups; 46 in the 7 days group vs 48.3% in the 14 days group suggesting that the 7-day course of antibiotic was non-inferior to the longer course.

 

Hence, patients who respond to the antibiotic may be given a 7-day treatment instead of 14 days.

 

(Reference: Yahav D, et al. Seven versus fourteen days of antibiotic therapy for uncomplicated gram-negative bacteremia: a non-inferiority randomized controlled trial. Clin Infect Dis. 2018 Dec 11. doi: 10.1093/cid/ciy1054. Epub ahead of print)

 

 

Dr KK Aggarwal

Padma Shri Awardee

President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)

Group Editor-in-Chief IJCP Publications

President Heart Care Foundation of India

Past National President IMA

To comment on this article,
create a free account.

Sign Up to instantly get access to 10000+ Articles & 1000+ Cases

Already registered?

Login Now

Most Popular Articles

News and Updates

eMediNexus provides latest updates on medical news, medical case studies from India. In-depth medical case studies and research designed for doctors and healthcare professionals.