EXTEND trial shows feasibility of thrombolysis beyond 4.5-hour window in selected patients
Thrombolysis for acute ischemic stroke is currently restricted to 4.5 hours from onset. But, the results of the EXTEND trial presented at the American Heart Association International Stroke Conference (ISC) has shown that ischemic stroke patients with salvageable brain tissue presenting 4.5-9 hours from onset or with WUS who received alteplase achieved better functional outcomes, reperfusion and early neurological improvement. Mortality was comparable despite numerically more symptomatic intracerebral h
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