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A small study found that insulin resistance measured with the surrogate marker HbA1c was strongly associated with fibromyalgia. This may hold implications for the treatment of this poorly understood pain syndrome.
In a cohort of 23 patients with fibromyalgia, levels of HbA1c were significantly higher than in two independent groups of controls, being 0.59 units higher than for participants in the Framingham Offspring Study (P<0.001), and 0.39 units higher than for individuals in the National Health and Nutrition Examination Survey (NHANES) dataset (P=0.0002), reported Miguel A. Pappolla of the University of Texas Medical Branch in Galveston, and colleagues online in PLoS One.
Among patients treated with metformin, 50% reported complete resolution of pain, a degree of improvement never observed before in such a large proportion of fibromyalgia patients subjected to any available treatment. Pappolla said that this could be a breakthrough for the treatment of fibromyalgia because the data are very clear-cut.