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Breaking news: Glucosamine supplements can lower CVD risks

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Dr KK Aggarwal    17 May 2019

(Medscape Excerpts) 

Patients who regularly take glucosamine supplements may have a moderately lower risk for cardiovascular disease (CVD) events, results from 22 centers participating in the UK Biobank suggest.

Glucosamine use was associated with a 15% lower risk for total CVD events and a 9% to 22% lower risk for stroke, coronary heart disease and CVD death after adjustment for age, sex, body mass index, race, lifestyle factors, diet, medications, and other supplements.

A few other cohort studies have raised this question including the Vitamins and Lifestyle (VITAL) cohort study, in which high glucosamine use (at least 4 days per week for at least 3 years) was associated with a 17% lower adjusted total mortality risk.

Animal studies suggest the associations may be driven by the anti-inflammatory properties of glucosamine or that the popular supplement may mimic a low carbohydrate diet by decreasing glycolysis and increasing amino acid catabolism, the authors write in their article published online May 14 in BMJ.

Dr KK Aggarwal

Padma Shri Awardee

President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)

Group Editor-in-Chief IJCP Publications

President Heart Care Foundation of India

Past National President IMA

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