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New GABA Modulator Promising in Depression
eMediNexus,  10 September 2019
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#Pharmacist #Psychiatry #Public Health

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SAGE-217, a novel modulator of γ-aminobutyric acid–A (GABAA), reduced depressive symptoms in patients with major depression in a new study.

Investigators compared patients who had major depression and were treated with SAGE-217 to patients who received placebo for a 2-week period. They found that a larger percentage of patients in the SAGE-217 group demonstrated a response to the treatment or remission, compared to those in the placebo group. There were no serious or severe adverse events. The study was published online September 5 in the New England Journal of Medicine.

 

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