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Menopausal estrogen-only therapy appears to lower risk of mortality significantly without harmful side effects among women treated in their 50s who had a hysterectomy and their ovaries removed, according to long-term follow-up from a study conducted at 40 US centers.
Results from the randomized, double-blind Womens Health Initiative (WHI) Estrogen-Alone Trial, published online in the Annals of Internal Medicine, followed 9939 women ages 50 to 79 years for an average 18 years. The mortality benefits of conjugated equine estrogens (CEE) did not extend to women who started estrogen therapy in their 60s or 70s, whether or not their ovaries were removed.