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Supplementing mammography with magnetic resonance imaging (MRI) for patients with dense breast tissue reduced the rate of interval cancers by half, but with a "concerning" rate of recall for additional imaging or interventions, Dutch investigators reported.
During the 2-year screening period, the rate of interval breast cancer was 2.5/1,000 mammographic screenings for women who underwent supplemental MRI and 5.0/1,000 in the patients who had mammography alone. Four of 20 interval cancers in the MRI group occurred in women who accepted the invitation for supplemental imaging (0.8/1,000), and the remaining 16 interval cancers occurred in women who declined the invitation (4/1,000). The findings were published in the New England Journal of Medicine.