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Four months of daily rifampicin is "short, safe, and effective" and is likely the best way to achieve the ambitious goal set forth by the World Health Organization (WHO) to treat 30 million patients for latent tuberculosis infection by 2022, TB experts say in Lancet Infectious Diseases.
Across randomized trials and observational studies, compared with isoniazid, four months of daily rifampicin has "consistently" shown better completion rates, lower toxicity, and similar effectiveness, they point out.