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Larger portions of women pregnant with fetuses with congenital heart disease (CHD) tested positive for stress, anxiety, and depression and this was tied to impairments in fetal brain development, a small case-control study found.
Almost two-thirds of pregnant women with fetuses with CHD tested positive for stress, 44% tested positive for anxiety, and about 30% tested positive for depression compared to around a quarter of pregnant women with healthy fetuses testing positive for stress and depression, reported Catherine Limperopoulos, PhD, of Childrens National Health System in Washington, D.C., and colleagues. Stress and depression in mothers was linked with impairments in fetal cerebellar and hippocampal development, the authors wrote in JAMA Pediatrics.