Cissus quadrangularis Salisb is a medicinal herb used to cure bone fractures. A study evaluated the impact of administration of C. quadrangularis Salisb extract (CQSE) on the histology of lumbar bone in ovariectomized experimental models. Sixteen models were segregated into 4 treatment groups, with 4 replications each. Group K0 comprised of ovariectomized models without CQSE supplementation. K1, K2 and K3 groups included ovariectomized models that were administered 300, 500 and 700 mg/kg body weight CQSE for 60 days, respectively. Densities of active osteoblast, passive osteoblast and osteoclast were assessed. Density of active osteoblasts in K3 models (27.25 ± 2.75) was significantly higher than those in K0 (1.75 ± 1.25), K1 (4.00 ± 1.41), and K2 (8.50 ± 7.40) groups, respectively (Fig. 1). Density of passive osteoblasts did not differ significantly among the groups - K0: 16.50 ± 6.13, K1: 41.00 ± 6.48, K2: 44.50 ± 16.34, and K3: 39.00 ± 15.23. Osteoclast density was found to be significantly higher in K0 (85.25 ± 25.91) compared to K1 (52.50 ± 16.66), K2 (51.00 ± 7.16), and K3 (50.75 ± 9.20) groups.

Administration of 700 mg/kg body weight of CQSE extract for a period of 60 days was thus shown to enhance active osteoblast density in ovariectomized models.

Fig. 1. Active osteoblast density in ovariectomized models in the study

Reference

1. Sabri M. Administration’s Effects of Ethanol Extract of Cissus quadrangularis Salisb on Growth of Lumbal Bone in Ovariectomized Rats. Jurnal Natural 2013;13(2):48-54.