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Potu and colleagues designed a study to determine the efficacy of petroleum ether extract of Cissus quadrangularis (CQ) on the development of osteopenia in ovariectomy-induced experimental models.
The models were ovariectomized or Sham operated. The ovariectomized models were randomized into four groups of eight models each. The groups included Sham operated (SHAM), Ovariectomized (OVX), Ovariectomized + treatment with 25 mg/kg body weight raloxifene (OVX+RAL), Ovariectomized + treatment with 500 mg/kg body weight extract of C. quadrangularis (OVX+ C. quadrangularis). The treatment was continued for a period of 30 days. Investigators assessed serum ALP, TRAP, calcium and hydroxyproline levels and histomorphometrical analysis was conducted using the left femur.
There was a significant increase in serum ALP, TRAP and hydroxyproline levels at the end of 1 month following ovariectomy in OVX models, in comparison with the SHAM group. There was further rise in ALP and TRAP levels in the OVX + RAL and OVX + C. quadrangularis groups following administration of the respective drugs. C. quadrangularis was shown to significantly increase the thickness of both cortical and trabecular bone. C. quadrangularis extract was thus shown to have a strong anti-osteoporotic effect.
- Potu BK, Nampurath GK, Rao MS, Bhat KM. Effect of Cissus quadrangularis Linn on the development of osteopenia induced by ovariectomy in rats. Clin Ter. 2011;162(4):307-12.