EXPLORE!

Skin Surface Lipidomics Reveals the Correlation Between Lipidomic Profile and Grade in Adolescent Acne

  1010 Views

eMediNexus Editorial    29 April 2020

Crucial factors of acne are increase in lipids secretion and changes of composition in the skin surface lipid (SSL). However, there are no studies relating the changes of lipid composition and content between different grades of adolescent acne, in lesional and non-lesional skin.

A new study published in the Journal of Cosmetic Dermatology investigated the correlation between the composition of SSL and different grades of acne, in order to understand the tendency of SSL alterations in individuals with acne for successful acne management and prevention.

This study entailed a powerful analytical technique, UPLC-QTOF-MS and multivariate data analysis to investigate the SSL variations of lipid main classes, subclasses and species.

The findings revealed that sphinganine, triradylglycerols (TG) and phytosphingosine were important in adolescent acne development. The average fatty acids (FAs) chain length in patients with acne showed a significantly shortened trend, from mild to moderate adolescent acne. While the relative average content of TG, diglyceride (DG), FA, ceramides (Cers) and the level of unsaturated FAs significantly increased from mild to moderate adolescent acne. Furthermore, the phytosphingosine and sphinganine showed an increasing trend in mild acne groups, but a decreasing trend in lesional skin of moderate group.

Hence, the lipidomics analysis suggested that the variation of TG, phytosphingosine and sphinganine was closely related to the occurrence severity of acne in adolescents.

Source: Journal of Cosmetic Dermatology. 2020 Apr 20. doi: 10.1111/jocd.13374.

To comment on this article,
create a free account.

Sign Up to instantly get access to 10000+ Articles & 1000+ Cases

Already registered?

Login Now

Most Popular Articles

News and Updates

eMediNexus provides latest updates on medical news, medical case studies from India. In-depth medical case studies and research designed for doctors and healthcare professionals.