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Derma Update : Efficacy and safety of microfocused ultrasound in moderate to severe atrophic acne scars

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eMediNexus    17 May 2020

The study was designed to evaluate the efficacy of microfocused ultrasound with visualization (MFU-V) in treating moderate to severe atrophic acne scars.

Healthy participants (N=20) who were in search of correction of moderate to severe atrophic acne scars on the cheeks and/or temples were registered. Scars were predominantly rolling and boxcar-type, which affected an area ≥5.0cm2. Total eighteen participants completed the study.

The treatment part was marked with 14mm2 and 25mm2 squares and was treated with four transducers: 7 MHz (3.0mm focal depth) and 10 MHz (1.5mm focal depth), each in 14mm and 25mm widths. During every session, MFU-V treatment lines were applied 2-3mm apart, in each treatment area, with a maximum stretch of 25mm. Each square had received 30 treatment lines at two transducer depths (60 total lines). The enrolled participants received three total treatments, with 30 days between each treatment session.

The primary outcome was improvement in baseline appearance of scars at 90 and 180 days after the final week of treatment. Secondary outcome measures included changes in severity using an Acne Scar Improvement Scale (ASIS) and Global Aesthetic Improvement Scale (GAIS) at 60, 90, and 180-days post-treatment with a satisfactory questionnaire at 90-days post-treatment.

Among the 90-day images available for evaluation (n=11), 100% were rated as improved by blinded reviewers, and 64% of pre and post treatment images were appropriately selected. Among 180-day images (n=15), 100% were assessed as improved, and 40% of pre and post treatment images were appropriately selected. Most participants were determined to have 25-50% improvement in investigator ASIS scores at 60, 90, and 180-days post-treatment. All participants observed some improvement in severity at the 60-day assessment. Depending on investigator GAIS scores, 100% of subjects were “Improved” or “Much Improved” at 60, 90, and 180 days post-treatment. Based on subject GAIS scores, all participants observed improvement at the 60 day assessment, and around 83% and 89% at the 90 and 180 day assessments, respectively. Overall, 17 subjects (94.4%) stated some degree of satisfaction at 90 days post-treatment.

The study demonstrated that MFU-V therapy is favorable and well tolerated for the treatment of rolling- and boxcar-type acne scars.

Source: Maas CS, Joseph JH. Safety and Effectiveness of Microfocused Ultrasound with Visualization for the Correction of Moderate to Severe Atrophic Acne Scars. J Drugs Dermatol. 2019 Nov 1; 18(11):1109-1114.

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