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Women tend to have a lower risk of nonalcoholic fatty liver disease compared with men; however, those who develop the disease have significantly greater likelihood than men to develop advanced fibrosis, suggests a meta-analysis of over 62,000 individuals.
A review and meta-analysis of 54 studies, including data from 62,239 patients with NAFLD, 5,428 with nonalcoholic steatohepatitis (NASH), and 6,444 with advanced NAFLD fibrosis, noted that women had a 19% lower risk of developing NAFLD compared to men (pooled risk ratio 0.81). Their risk of developing NASH was similar as men (RR, 1.00), but they had a 37% increased risk of advanced fibrosis (RR, 1.37) compared to men. The findings are published in Clinical Gastroenterology and Hepatology… (Medscape)