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Alloveda Liver Update: Efficacy and safety of a polyherbal formulation in alcoholic liver cirrhosis

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eMediNexus    06 August 2020

A study was conducted to determine the clinical efficacy and safety of a polyherbal formulation containing Capparis spinosa, Cichorium intybus, Solanum nigrum, Cassia occidentalis, Terminalia arjuna, Achillea millefolium, and Tamarix gallica, in alcoholic liver cirrhosis.

This open clinical trial enrolled patients suffering from early alcoholic cirrhosis. Patients with evidence of esophageal varices, hepatic encephalopathy and malignant jaundice, and pregnant women were excluded from the study. A thorough history was obtained, and symptomatic evaluation and clinical examination were carried out for all patients prior to treatment and during follow-up visits every month till the end of treatment after 6 months. Liver function tests, hemogram and other biochemical tests were conducted at baseline and at the end of the study. The primary endpoints included rapid relief from clinical symptoms and physical signs along with improvement of efficacy biochemical parameters. The secondary endpoints included short- and long-term safety, and overall compliance to the drug treatment.

Fifty patients were enrolled in the trial. There was a significant reduction in the clinical symptom scores for asthenia, easy fatigability, tiredness, nausea, anorexia, abdominal discomfort, abdominal pain, stool frequency and muscle cramps; as well as in the physical sign scores of muscle wasting, jaundice, anemia, edema, ascites, and hepatomegaly. There was a significant decrease in liver function test parameters including alanine transaminase, aspartate transaminase, total bilirubin, alkaline phosphatase, albumin, and prothrombin time at the end of 6 months of treatment with the herbal formulation. No clinically significant adverse events were noted during the study.

This polyherbal formulation thus seems to be clinically safe and effective in the management of alcoholic liver cirrhosis.

Source: Agal S, Prasad SR, Mitra SK. Liv.52 DS Tablets: Evaluation of Efficacy and Safety in Alcoholic Liver Cirrhosis. Medicine Update 2007;15(6):25-32.

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