EXPLORE!

Are FDA-Approved Sunscreen Components Effective in Preventing Solar UV-Induced Skin Cancer?

  618 Views

eMediNexus    08 August 2020

Solar ultraviolet (SUV) exposure is a major risk factor in the etiology of cutaneous squamous cell carcinoma (cSCC). People commonly use sunscreens to prevent SUV-induced skin damage and cancer. Yet, the prevalence of cSCC continues to increase every year.

A new study published in Cells investigated the efficacy of eight commonly used FDA-approved sunscreen components against skin carcinogenesis.

Here, FDA-approved sunscreen components were testedfor their ability to block UVA or UVB irradiation. Thereafter, the efficacy of FDA-approved sunscreen components was investigated.

FDA-approved sunscreen components or combinations that are effective in preventing cSCC development were identified. The results indicated that sunscreen combinations that block both UVA and UVB significantly suppressed the formation of cutaneous papillomas and cSCC development and decreased the activation of oncoproteins and the expression of COX-2, keratin 17 and EGFR in solar simulated light (SSL)-exposed skin. However, several sunscreen components that were individually purported to block both UVA and UVB were ineffective alone.

Hence, the results provided new insights into the development of the best sunscreen to prevent chronic SUV-induced cSCC development.

Source: Cells. 2020 Jul 11;9(7):E1674.doi: 10.3390/cells9071674.

To comment on this article,
create a free account.

Sign Up to instantly get access to 10000+ Articles & 1000+ Cases

Already registered?

Login Now

Most Popular Articles

News and Updates

eMediNexus provides latest updates on medical news, medical case studies from India. In-depth medical case studies and research designed for doctors and healthcare professionals.