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The U.S. Food and Drug Administration has granted approval to oliceridine, an opioid agonist to manage moderate to severe acute pain in adults, where the pain is severe enough to need an intravenous opioid and alternative treatments are inadequate.
Oliceridine is indicated for short-term intravenous use in hospitals or other controlled clinical settings, for instance, during inpatient and outpatient procedures. The drug is not indicated for at-home use. Controlled and open-label trials assessed the opioid in 1,535 patients with moderate to severe acute pain. It was compared to placebo in randomized, controlled studies of patients who underwent bunion surgery or abdominal surgery. Patients given oliceridine had decreased pain compared to placebo at the approved doses… (FDA, August 7, 2020)