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#Gastroenterology #Hepatology #Multispeciality
There are several biomarkers associated with liver status which are affected by excessive alcohol consumption. The impact of alcohol quantity; however, has not been clearly elucidated on biochemical changes and oxidative stress in ALD patients.
The present study sought to ascertain the alteration in biochemical parameters associated with liver functions, antioxidant levels and oxidative stress in ALD patients (both moderate and heavy drinkers).
In all, 260 subjects were enroled and segregated into three groups: Group I included 75 diagnosed cases of ALD with moderate drinkers, Group II had 92 diagnosed cases of ALD with heavy drinkers, while Group III included 93 normal healthy controls.
The levels of serum enzymes, including aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and γ-glutamyl transferase (GGT), total protein, total bilirubin and lipid parameters such as total cholesterol, triglyceride, high density cholesterol (HDL) and low density cholesterol (LDL), were quantified using fully automated chemistry analyzer. The levels of antioxidants such as superoxide dismutase (SOD), catalase (CAT) and oxidative stress marker such as malondialdehyde (MDA) were estimated using spectrophotometric method.
Serum levels of AST, ALT, ALP, GGT, total bilirubin total cholesterol, triglyceride, LDL, VLDL and plasma MDA were found to be significantly increased while serum total protein, blood levels of SOD and CAT activity were shown to be significantly decreased in ALD with moderate drinkers as well as ALD with heavy drinkers groups, in comparison with healthy controls, respectively. While comparing ALD with moderate drinkers group with ALD with heavy drinkers group, there appeared to be a significant difference only for LDL cholesterol, serum total bilirubin and plasma MDA.
Alcohol-induced liver injury was thus found to be associated with significant alteration in several biochemical parameters and oxidative stress as evident by reduced levels of antioxidants in moderate as well as in heavy drinkers.
Source: Makwane H, Kare PK, Verma M.Alteration in Biochemical and Antioxidant Parameters in Patients with Alcoholic Liver Injury.Journal of Clinical and Diagnostic Research 2020;14(3):8-11.