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#Diabetes and Endocrinology #Internal Medicine #Pharmacist
According to new research, regular use of proton pump inhibitors (PPIs) is associated with modest duration-dependent risk for developing type 2 diabetes.
In a prospective study of three large U.S. cohorts, and in more than 2,127,471 person-years of follow-up, 10,105 incident cases of diabetes were noted, with regular PPI users, having a hazard ratio of 1.24 (95% CI 1.117-1.31) compared to non-users, reported researchers. As the duration of PPI use increased, fully adjusted HRs increased to 1.05 (95% CI 0.93-1.19) for >0 to 2 years of use and 1.26 (95% CI 1.18-1.35) for >2 years, in comparison with no PPI use, stated the investigators in Gut. The authors stated that caution should be exercised while prescribing PPIs, especially for long-term use… (Medpage Today)