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#Gastroenterology #Hepatology #Multispeciality
Malnutrition has a key role to play in the pathogenesis for sarcopenia. Both food consumption and energy intakes decline with age. A major factor responsible for reduced energy intakes is anorexia of ageing. A study by Tsutsumimoto et al evaluated the association between anorexia of ageing and sarcopenia among community-dwelling elderly individuals.
Anorexia of ageing was assessed using a simplified nutritional appetite questionnaire. Handgrip strength and walking speed were evaluated, and skeletal muscle mass was assessed. Subjects with sarcopenia were defined as those fulfilling the criteria of the Asian Working Group for Sarcopenia. The association between anorexia of ageing and sarcopenia was analyzed using multiple regression analysis.
Overall, 9,496 elderly individuals, mean age 74.1 ± 5.4 years, were evaluated (male 47.0%). Anorexia of ageing was prevalent in 9.8% subjects. The prevalence of sarcopenia in men was 1.1%, 1.8%, 6.1%, 10.1%, and 21.2% and was 1.6%, 3.3%, 3.6%, 4.8%, and 7.4% in women in the 65-69, 70-74, 75-79, 80-84, and 85 years and older age groups, respectively. There was an age-dependent increase in the prevalence of anorexia as well in both sexes. The prevalence of anorexia in men was 8.3%, 6.3%, 9.8%, 13.6%, and 12.9% and was 7.9%, 9.4%, 10.5%, 17.6%, and 17.1% in women in the aforementioned age groups, respectively. Multivariable logistic regression model, adjusted for the covariates except for albumin, revealed that anorexia of ageing was independently associated with sarcopenia (OR: 1.45, 95% CI: 1.07 to 1.95; P = 0.015). This significant association persisted even after adjusting for all covariates including nutritional status (OR: 1.42, 95% CI: 1.06 to 1.92, P = 0.020). Anorexia of ageing was thus found to be associated with sarcopenia among elderly individuals in the present study.
Source: Tsutsumimoto K, Doi T, Nakakubo S, et al. Association between anorexia of ageing and sarcopenia among Japanese older adults. J Cachexia Sarcopenia Muscle. 2020 Mar 19.