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COVID-19 Vaccine Updates
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In a biorepository study including 64 women with SARS-CoV-2 infection, no maternal viremia, placental infection, or vertical transmission of SARS-CoV-2 was observed, reported researchers in JAMA Network Open.
However, SARS-CoV-2 antibodies were found to transfer relatively inefficiently across the placenta in the third trimester, pointing that neonates whose mothers had COVID-19 during pregnancy may still be susceptible to the virus. Evidence from another study suggest that antibodies may transfer more efficiently with second-trimester infections.
Investigators stated that while low rates of maternal viremia and patterns of placental SARS-CoV-2 receptor distribution may explain the rarity of vertical transmission, reduced transplacental transfer of antibodies may leave neonates at risk for infection… (Medscape)