Typhoid fever is among one of the utmost common bacterial causes of acute febrile illness in the evolving world, estimated around 10.9 million new cases and 116.8 thousand deaths in 2017. Typhoid point-of-care (POC) analytical tests are extensively used but have poor compassion and specificity, resulting in antibiotic overdoing that has led to the occurrence and spread of multidrug-resistant strains. Through latest developments in typhoid surveillance and detection, this is the ultimate time to produce a target product profile (TPP) that guides product development and make sure that a next-generation test meets the requirements of users in the resource-limited settings where typhoid is prevalent.

This information summaries the first widespread TPP for typhoid fever and is proposed to guide the growth of a next-generation typhoid diagnostic test. An exact POC test will lessen the morbidity and mortality of typhoid fever through quick diagnosis and treatment and will have the greatest influence in reducing antimicrobial resistance, if it is united with diagnostics for other sources of acute febrile illness in a treatment algorithm.

Source: BMJ Glob Health. 2019 Oct 31;4(5):e001831.