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Alloveda Liver Update: EASL Clinical Practice Guidelines: Drug-induced liver injury

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eMediNexus    04 March 2021

Idiosyncratic(unpredictable) drug-induced liver injury is one of the most challenging liverdisorders faced by hepatologists, because of the myriad of drugs used inclinical practice, available herbs and dietary supplements with hepatotoxicpotential, the ability of the condition to present with a variety of clinicaland pathological phenotypes and the current absence of specific biomarkers.This makes the diagnosis of drug-induced liver injury an uncertain process,requiring a high degree of awareness of the condition and the careful exclusionof alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity canbe severe, leading to a particularly serious variety of acute liver failure forwhich no effective therapy has yet been developed. This is an ongoingprospective study and is likely to lead to important contributions to the fieldof DILI in the future. In addition to DILI registries, single-centre cohortstudies from India and Turkey have also been reported, withantibiotics/antituberculosis (anti-TBC) drugs being the most prominentcausative agents of DILI

Source:Journal of Hepatology 2019

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