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Depressive Symptoms and Inflammatory Diet Tied to Higher Frailty Risk

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eMediNexus    31 March 2021

Depressive symptoms and a pro-inflammatory diet, including red meat, refined carbohydrates, and sweetened beverages, seem to heighten the risk of frailty in adults, according to new research.

New findings from the Framingham Heart Study suggest that adults with depressive symptoms who consumed such a diet had a 28% higher likelihood of developing frailty compared to their counterparts who did not have depression, but consumed a pro-inflammatory diet. Over a 16-year period, 227 participants became frail. The mean dietary inflammatory index (DII) for the study group was –0.17. The mean DII for frail individuals was 0.08 while that for nonfrail individuals was –0.20. A more positive score indicates a more pro-inflammatory diet. The mean Center for Epidemiologic Studies Depression (CES-D) score at baseline was significantly higher in frail individuals compared to nonfrail ones. After the investigators adjusted for baseline age, sex, energy intake, smoking, diabetes treatment, cardiovascular disease, and nonmelanoma cancers, a one-unit higher DII was tied to 13% higher likelihood of developing frailty in those with no depressive symptoms (CES-D < 16) and 41% higher odds in those having depressive symptoms (CES-D > 16). The study was presented at the virtual Anxiety and Depression Association of America (ADAA) Conference 2021… (Medscape)

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