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Complement in ANCA Vasculitis and IgA nephropathy: Should We Target or Still a Wait Period?

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Dr Anna T Valson, Vellore    09 January 2018

  1. IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis worldwide, with patients bearing a broad spectrum of clinical and pathological changes (Zhu L, et al. Kidney Dis. 2015;1(1):27-32).
  2. Complement C3 causes HMCs to convert to the synthetic phenotype and stimulates growth of mesangial cells, suggesting that C3 may play an important role in phenotypic regulation of mesangial cells in renal diseases (Wan JX, et al. J Cell Physiol. 213:495-501).

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