Arsenic trioxide + all-trans retinoic acid: A new standard of care for acute promyelocytic leukemia in children? |
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Arsenic trioxide + all-trans retinoic acid: A new standard of care for acute promyelocytic leukemia in children?
Dr Swati Y Bhave, Adjunct Professor in Adolescent Medicine; Dr D Y Patil Medical College, & Dr D Y Patil Vidyapeeth, Pune Senior consultant, Adolescent Pediatrics & Head-In-charge of Adolescent Wellness Clinic, Jehangir Hospital Pune,  19 November 2021
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Children with acute promyelocytic leukemia (APL) can be safely and effectively managed with the combination of arsenic trioxide and all-trans retinoic acid (ATRA) without maintenance therapy, according to a report from the Children’s Oncology Group AAML1331 Trial published in JAMA Oncology. The combination also significantly reduced the use of chemotherapy.The multicountry nonrandomized, noninferiority trial enrolled 154 children, aged 1 to 21 years, with newly diagnosed APL at 85 ped...
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