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Heavy Snoring in Early Pregnancy Tied to Increased Insulin Resistance

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eMediNexus    13 January 2022

Severe maternal sleep-disordered breathing (SDB) increases the risk for gestational diabetes. A new study has now shown that increased insulin resistance, a precursor for gestational diabetes, may occur as soon as in the first trimester among women with risk factors for obstructive sleep apnea (OSA), like overweight and habitual snoring.

Women with early singleton pregnancies and risk factors for OSA, including habitual snoring and a median body mass index (BMI) of at least 27 kg/m2, were enrolled in the study from two prospective clinical trials. Overall, 192 women underwent in-home sleep study (HSAT) and homeostatic model assessment (HOMA).

Sixty one women (32%) were diagnosed with OSA. They had a higher likelihood of being older, have a high BMI, and be multipara, in comparison with women who didn′t have a diagnosis of OSA. Women diagnosed with OSA had higher glucose and C-peptide levels and a higher degree of insulin resistance, in comparison with those without OSA, reported the researchers in Sleep… (Medscape)

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