Antiviral Therapy Update: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis |
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Antiviral Therapy Update: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

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Molnupiravir is an orally administered antiviral drug proposed for managing COVID-19 patients. It has been shown to enhance viral RNA mutations and deform SARS-CoV-2 replication in animal models and humans. A study explained the molecular mechanisms of molnupiravir-induced RNA mutagenesis by utilizing viral RNA-dependent RNA polymerase (RdRp). RdRp uses the active form of molnupiravir, β-D-N4-hydroxycytidine (NHC) triphosphate, as a substrate has been proven by the Biochemical assays. ...
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