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Alleviating Skin Barrier Disruption, Skin Inflammation and Pruritus with a Moisturizing Spray

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eMediNexus    12 August 2022

The purpose of a recent study was to explore the relationship between skin inflammation, skin barrier function and pruritus using an animal model, and to investigate the efficacy of the combined application of β-glucan and panthenol in a moisturizing spray.

For this experiment, a dry skin-induced chronic pruritus mouse model was established by repeated acetone-ether-water (AEW) treatment of the skin. The effects of a spray containing β-glucan and panthenol were observed.

It was observed that AEW treatment triggered spontaneous scratching rendering multiple scratching bouts and compromised skin barrier with a marked increase in transepidermal water loss (TEWL) values as well as a significant decrease in filaggrin gene (FLG) expression. Additionally, AEW treatment notably suppressed the expression of NOD-like receptor family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing a CARD (ASC), caspase-1, interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), as well as the pruritis-associated molecules nerve growth factor (NGF), cathepsin S (CTSS) and thymic stromal lymphopoietin (TSLP) in the skin. While the application of β-glucan and panthenol spray significantly attenuated these responses. This combination reduced the number of scratching bouts within an hour, and also reduced the TEWL values, heightened FLG mRNA expression and reduced mRNA levels of NLRP3, ASC, caspase-1, IL-1β, TNF-α, CTSS, TSLP and NGF in skin lesions.

The findings depicted a relationship between damaged skin barrier function, pruritus and inflammation. Further, it was stated that adding β-glucan and panthenol to moisturizing skin care products may alleviate pruritus induced by dry skin, improve the damaged skin barrier function and reduce the local inflammatory state.

Source: Zhu J, Wang YF, Song SS, et al. Alleviating skin barrier disruption, skin inflammation and pruritus: a moisturizing spray containing β-glucan and panthenol. Int J Dermatol Venereol. May 28, 2022. Doi: 10.1097/JD9.0000000000000248

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