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PPIs shown to increase fracture risk in dialysis patients
eMediNexus,  28 September 2018
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#Internal Medicine #Nephrology #Orthopedics #Pharmacist

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The use of proton pump inhibitors (PPIs) was associated with a 19% higher risk of hip fracture in patients with kidney failure on dialysis, as per a study published Sept. 27, 2018 in the Clinical Journal of the American Society of Nephrology (CJASN). The association remained within subgroups of low, moderate, and high use, yielding of 16%, 21%, and 19% greater risks, respectively. Histamine-2 receptor antagonists were not associated with hip fracture events.
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