eMediNexus Coverage from:  RSSDI 2018
CVOTs with GLP-1 Receptor Agonists: How Significant?
Dr Ajay Kumar, Patna,  27 November 2018
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#Cardiology #Diabetes and Endocrinology

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GLP-1 may affect cardiac function indirectly through its actions on pancreatic islets to increase insulin secretion and inhibit glucagon secretion. Evidence points to a reduction in systolic BP with GLP-1 RAs. GLP-1 RAs also improve CV-risk biomarkers.Several CVOTs have been conducted with GLP-1 RAs and some are still underway. In the LEADER trial, in the time-to-event analysis, the rate of the first occurrence of CV death, nonfatal MI or nonfatal stroke was lo
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