The American Academy of Pediatrics (AAP) has published new clinical practice guideline for the management of infantile hemangiomas.

Published online Dec. 24, 2018 in Pediatrics, the guideline says that “unlike many diseases, management of IHs is not limited to one medical or surgical specialty. A hemangioma specialist may have expertise in dermatology, hematologyoncology, pediatrics, facial plastic and reconstructive surgery, ophthalmology, otolaryngology, pediatric surgery, and/or plastic surgery, and his or her practice is often focused primarily or exclusively on the pediatric age group.”

Some key recommendations include:

• Infantile hemangioma associated with life-threatening complications, functional impairment or ulceration or risk thereof, structural anomalies (e.g., in PHACE syndrome or LUMBAR syndrome), or permanent disfigurement is high risk. Once the hemangioma is classified as high risk, the patient should be evaluated by a hemangioma specialist as soon as possible.
• Imaging should be done only when the diagnosis is uncertain, there are ≥5 cutaneous hemangiomas, or associated anatomic abnormalities are suspected. Ultrasonography is recommended as the initial imaging modality when the diagnosis of IH is uncertain. MRI may be done if associated structural abnormalities (e.g., PHACE syndrome or LUMBAR syndrome)
• Oral propranolol (2-3 mg/kg/day) is the first-line agent for hemagiomas requiring systemic treatment; but, in the presence of comorbidities or adverse effects, a lower dose is recommended.
• Propranolol is to be administered with or after feeding and doses be held at times of diminished oral intake or vomiting to reduce the risk of hypoglycemia.
• Clinicians should evaluate patients for and educate caregivers about potential adverse effects of propranolol, including sleep disturbances, bronchial irritation, and clinically symptomatic bradycardia and hypotension.
• When propranolol is contraindicated or response to propranolol is poor, oral prednisolone or prednisone may be used.
• Intralesional injection of triamcinolone and/or betamethasone can be given to treat focal, bulky hemangiomas during proliferation or if they are located in  certain critical anatomic areas such as the lip.
• In cases of thin and/ or superficial hemangiomas, topical timolol maleate may be prescribed.
• Surgery and laser therapy may be indicated if the lesion has failed to improve with local wound care and/or pharmacotherapy; the lesion is well localized, and early surgery will simplify later reconstruction (e.g., a prominent hemangioma involving the ear or eyelid); the lesion is well localized in an anatomically favorable area or resection is likely to be necessary in the future, and the resultant scar would be the same
• Clinicians should educate parents of infants with the hemangioma about the condition, including the expected natural history, and its potential for causing complications or disfigurement.

(Source: Krowchak DP, et al; Subcommittee on the Management of Infantile Hemangiomas. Pediatrics Dec 2018, e20183475; DOI: 10.1542/peds.2018-3475)

Dr KK Aggarwal

Padma Shri Awardee

President Elect Confederation of Medical Associations in Asia and Oceania   (CMAAO)

Group Editor-in-Chief IJCP Publications

President Heart Care Foundation of India

Immediate Past National President IMA