• Indications for placebo therapy include self-resolving conditions, non-disease, conditions without effective treatments, disease sequelae, diseases with marked psycho-social impact, recurrent diseases, as a bridge to other specialties.
• Disease and patient factors as well as physician factors work towards the making placebos effective.
• The disease and patient factors are:

o  Spontaneous remission

o  Normal symptoms fluctuation

o  Complex neurobiologic mechanism that mimic those of many medications

o  Genetic predisposition.

• Physician factors making placebo effective are:

o  Therapeutic setting

o  Engagement with physicians

o  Empathetic environment

o  Faith and trust.