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Systems Biology for Kidney Disease in Diabetes

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Prof (Dr) Kumar Sharma, USA    29 November 2019

  • Reduced mitochondrial function characterizes diabetic kidney disease (DKD) in mice and humans.
  • Evidence of enhanced glycolysis in DKD and with high glucose in kidney cells.
  • Mitochondrial dysfunction may be linked to altered sphingomyelin production and tricarboxylic acid metabolites (fumarate) and enhance Warburg effect.
  • Possible role for p53/MDM2 in regulating progression and possible link to metabolic reprogramming.
  • Warburg effect possibly driven by mismatch of nutrients to cell mass and may be a driver of disease progression.

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