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Hypertension During Dialysis

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Dr Vinod Kumar K, Kerala    02 December 2019

  • Intradialytic hypertension has a prevalence of 5-15%.
  • It is associated with high risk of overall mortality and cardiovascular mortality.
  • Volume overload and endothelial dysfunction plays a major role in the pathogenesis.
  • Renin activation and sympathetic nervous system activation are also implicated in the pathogenesis.
  • Probing the dry weight, fluid control and sodium restriction plays a vital role in controlling the hypertension during hemodialysis.
  • Carvedilol, a non-specific β-blocker, with vasodilating properties, if found to be beneficial.
  • Other medications like long-acting α- and β-blocker, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) can also be utilized for the treatment.
  • Increasing the frequency and duration of dialysis sessions, helps to control intradialytic hypertension.
  • Renal sympathetic denervation can be considered refractory cases.
  • Other secondary causes have to be ruled out and managed appropriately in selected cases.

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