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Asprosin is a centrally acting hormone that promotes appetite. It also aids in glucose production in the liver.
A study by Hu et al evaluated the difference in plasma asprosin level between patients with anorexia nervosa (AN) and healthy controls. Investigators also assessed the relationship between asprosin changes and plasma glucose levels and AN symptoms.
Forty six AN patients and 47 healthy controls were enrolled in the study. Plasma asprosin and glucose concentrations were evaluated in AN patients and healthy control subjects. Eating Disorder Inventory-2 (EDI-2) was employed to determine eating disorder symptoms and related personality traits. The concomitant levels of depression and anxiety in the patients were quantified with the help of beck depression inventory and beck anxiety inventory, respectively.
AN patients were reported to have a higher asprosin concentration in the plasma compared to healthy controls. Among AN patients, plasma asprosin levels had a positive correlation with EDI-2 interoceptive awareness subscale score (p = 0.030) and a negative correlation with duration of illness (p = 0.036). According to the multiple linear regression analyses, elevated asprosin levels (p = 0.029), glucose levels (p = 0.024) and body mass index (p = 0.003) were linked with an increase of the score of EDI-2 bulimia subscale.
Elevated plasma asprosin concentration in patients with AN may serve as a compensation for the bodys energy shortage. Asprosin seems to have a role in the development of bulimia and lack of interoceptive awareness in AN patients, concluded the researchers.
Source: Hu Y, Xu Y, Zheng Y, et al. Increased plasma asprosin levels in patients with drug-naive anorexia nervosa. Eat Weight Disord. 2020 Feb 5.