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Alloveda Liver Update: Link between Hepatitis B Infection and Chronic Kidney Disease: 10-Year Results From an Inpatient Sample

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eMediNexus    05 July 2020

Viral hepatitis adversely affects renal function that could possibly result in nephropathy. A recent study explored the associations between chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) and/or end-stage renal disease (ESRD) in a large, representative nationwide U.S. sample.

The population-based, retrospective observational study used data from the U.S. Nationwide Inpatient Sample (NIS) database that included adults ≥18 years old admitted to U.S. hospitals from 2005 to 2014 with their medical history showing evidence of chronic HBV infection. The final sample included 70,674 HBV-infected patients and 282,696 matched non-HBV controls. Study endpoints included prevalent CKD and ESRD. Investigators assessed the associations between CKD/ESRD and HBV and patients clinical characteristics.

HBV infection was found to be linked with a marginally increased risk of prevalent CKD (OR: 1.06, 95% CI: 1.004-1.119) and nearly double the risk of prevalent ESRD (OR: 1.98, 95% CI: 1.880-2.086). HBV infection in both males and females was tied to slightly increased risk of CKD (males, OR: 1.09, 95% CI: 1.02-1.16; females, OR: 1.07, 95% CI: 0.98,1.17). It also had a significant association with increased risk for CKD among non-diabetic patients (OR: 1.23, 95% CI: 1.15-1.32), white patients (OR: 1.14, 95% CI: 1.06-1.23) and Asian/Pacific Islanders (OR: 1.13, 95% CI: 0.98-1.30).

Investigators concluded that chronic HBV infection was linked with slightly increased risk for CKD and greater risk for ESRD. HBV infection was associated with a heightened risk for CKD among Whites and Asian/Pacific Islanders and non-diabetic patients.

Source: Geng X-X, Tian Z, Liu Z, et al. Associations Between Hepatitis B Infection and Chronic Kidney Disease: 10-Year Results From the U.S. National Inpatient Sample. Enferm Infecc Microbiol Clin. 2020 Apr 22;S0213-005X(20)30165-8.

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