Alloveda Liver Update: Impact of an herbal formulation in acute alcoholic hepatitis |
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Alloveda Liver Update: Impact of an herbal formulation in acute alcoholic hepatitis

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A study was conducted to determine the clinical efficacy and safety of a polyherbal formulation, containing Capparis spinosa, Cichorium intybus, Mandura bhasma, Solanum nigrum, Terminalia arjuna, Cassia occidentalis, Achillea millefolium and Tamarix gallica, in acute alcoholic hepatitis. This open, prospective clinical trial included 34 male patients with a mean age of 45.88 ± 9.52 years. All the patients were administered the herbal formulation as two tablets, thrice daily for 4 months. Clinical evaluation for jaundice, anorexia, nausea/vomiting, fever and pruritus was scored at initiation and monthly thereafter for four months.

Treatment with the herbal formulation led to significant improvement in clinical signs and symptoms as well as biochemical parameters. The overall impression by the investigator demonstrated considerable improvement in 7.41%, moderate improvement in 33.33%, slight improvement in 33.33% and no change in 25.92% of the cases. The overall impression by the patients showed cure in 3.7%, marked improvement in 11.11%, moderate improvement in 7.41%, slight improvement in 55.56% and no change in 22.22% of the cases.

Significant relief from the clinical symptoms was observed from 2nd month of treatment and improvement continued until the end of the study period. Significant improvement was also noted in liver function parameters. There were no adverse reactions during the study period and overall compliance to the treatment was adequate.

The polyherbal formulation thus seems to be an effective and safe therapeutic option in patients with alcoholic hepatitis.

Source: Dange SV, Nikam A, Kamale M. Evaluation of Efficacy and Safety of Liv.52 Tablet in Acute Alcoholic Hepatitis: An Open Clinical Study. Indian Journal of Clinical Practice 2011; 2(7):325-9.

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