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DiabetesIndia 2022: Mechanism of β-cell Dysfunction in T2DM

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Dr Om Lakhani, Ahmedabad    07 July 2022

  • Over 50% of β-cell function is lost at the time of diagnosis along with a 4-5% reduction every year in T2D patients.
  • Beta-cell impairment is the key to the pathogenesis of T2D.
  • In comparison to the insulin resistance in a prediabetic patient, diabetic patients have both insulin resistance and β-cell dysfunction as insulin secretion is a cumulative factor of β-cell mass and its function.
  • Preservation of β-cell is the key to preventing progression from prediabetes to T2D and further disease progression in T2D patients itself.

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