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CANVAS Program

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Dr Bruce Neal, UK    01 February 2018

  1. Inclusion criteria: Patients with type 2 diabetes - HbA1c ≥7.0% to ≤10.5%; eGFR ≥30 mL/min/1.73 m2; age ≥30 years and history of prior CV event; OR age ≥50 years with ≥2 CV risk factors (diabetes duration ≥10 years, SBP >140 mmHg on ≥1 medication, current smoker, micro- or macroalbuminuria or HDL-C <1 mmol/L).
  2. The CANVAS Program met its primary objective of demonstrating the CV safety and efficacy of canagliflozin.
  3. The data suggest a favorable benefit/risk profile with canagliflozin treatment in many patients with type 2 diabetes and high CV risk.
  4. During the discussion/questions session, the risk of amputation and fractures was discussed among the audience members and the speaker, and it was concluded that there has been no increased risk of fractures or amputations in patients in real clinical practice.
  5. The increased risk of amputation may be there only in patients who have a history of amputation.

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