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Lipodystrophies: Clinical Phenotypes and Underlying Mechanisms

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Dr Justin Rochford, UK    26 November 2018

  1. Lipodystrophies are a range of metabolic conditions that may be acquired or inherited, which feature altered mass or distribution of adipose tissue.
  2. The genetic causes of inherited lipodystrophies are varied and confer a range of clinical phenotypes but typically include insulin resistance, hepatic steatosis and CVD.
  3. Lipodystrophies can affect different adipose tissue depots, revealing insights regarding their different metabolic properties and developmental origins.
  4. Studying lipodystrophies is important in order to discover novel clinical approaches to treat this serious, rare condition. However, it can also uncover insights regarding the nature of adipose tissue development and function and how this might be altered to prevent or treat more common forms of diabetes.

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