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Asian Indian Phenotype

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Dr Mala Dharmalingam, Bengaluru    26 November 2018

  1. The “Asian Indian Phenotype” refers to certain unique clinical and biochemical abnormalities in Indians which include: Increased insulin resistance; greater abdominal adiposity; higher waist circumference despite lower BMI; lower adiponectin and higher hsCRP levels.
  2. Asian Indian phenotype is uniquely predisposed to develop T2DM because of strong familial aggregation as well as lifestyle factors of imprudent diet and sedentary physical habit.
  3. The typical Asian Indian phenotype is the “thin-fat Indian” which means that Asian Indians have higher body fat composition and lesser musclemass (sarcopenia) than the White or African counterparts.
  4. Aggressive screening and treatment strategies are advocated in this high-risk diabetic race.
  5. Prevention is the key for diabetes in Indians, and simple prevention themes like “Eat less, eat on time, eat right, walk more, sleep well and smile” are needed.

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