Genetic Studies in Chronic Pancreatitis: Separating the Grain from the Chaff |
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Genetic Studies in Chronic Pancreatitis: Separating the Grain from the Chaff

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Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene.Hereditary pancreatitis is clinically indistinguishable from other forms and varieties of pancreatitis.Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis.Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.Genes which...
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