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Dr Gaurav Pande 05 December 2018

The complexity of the clinical presentation of both infections and inflammation creates the need of biomarker that can reliably differentiate.
PMNs can express 3 classes of Ig G receptors. These receptors are recognized by the monoclonal antibodies CD64 (FcgRI), CD32 (FcgRII), and CD16 (FcgRIII), respectively.
CD64 is constitutively expressed on macrophages, monocytes, and eosinophils.
Neutrophil CD64 expression is a physiological response to microbial wall components, complement split products, and pro-inflammatory cytokines.
According to an observational, cross-sectional study that compared CD64 expression on neutrophils between patients with SAH - with/without bacterial infection:

1. CD64 expression on neutrophils was higher in patients with bacterial infection
2. CD64 expression on neutrophils was higher in non-survivors at D8 with sepsis
3. CD64 has a higher sensitivity and specificity than CRP and TLC in differentiating sepsis from non-infected patients with SAH
4. CD64 could be a potential marker for early identification of infection.

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