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CDI: Pathophysiology, Diagnosis, New Guidelines on Therapy, Novel Treatments, Immunity and immunization

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Prof Ciaran P Kelly, USA    05 December 2018

  • Increasing burden of disease.
  • Factors contributing to increased incidence and severity
  1. Host factors: Age; Immune response; Underlying disease
  2. C. difficile bacterial factors: Virulence; Antibiotic resistance
  3. Environmental factors
  • 2017 IDSA-SHEA guidelines on
  1. CDI diagnosis: Know your algorithm
  2. CDI treatment: Mild-moderate-severe- Vanco or Fidaxo; Fulminant-Vanco + Metro IV; First recurrence; Second or subsequent recurrences
  • Novel approaches
  1. Live bacterial therapies
  2. Passive immunotherapy using anti-toxin antibodies (Bezio)
  3. Active vaccine elusive thus far.

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