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A Case of Late Rejection

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Dr Ajay Kher, Noida    27 December 2018

  • Most late rejections are due to low immunosuppression (non-compliance or iatrogenic).
  • Late rejections are associated with de novo donor-specific antibodies and worse graft outcomes.
  • Treatment focuses on cellular rejection, antibody rejection or both, depending on biopsy findings.
  • Prevention: Focus on reducing noncompliance, especially in high-risk patients and increased frequency of monitoring to prevent late detection of rejection.

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