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Pathogenesis of Pre-eclampsia: Implications for Cardiovascular and Chronic Renal Disease

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Dr S Ananth Karumanchi    31 December 2018

  • Pre-eclampsia is associated with maternal endothelial dysfunction that is mediated by an imbalance in circulating angiogenic factors.
  • Circulating angiogenic factors can be used for the early diagnosis and prognosis of pre-eclampsia.
  • Reversal of angiogenic imbalance is associated with improvement in hypertension, proteinuria and extension of pregnancy.
  • Vascular damage induced by pre-eclampsia can lead to chronic CV and renal disease.

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