Emerging Systemic Therapy: JAK Inhibitors |
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Emerging Systemic Therapy: JAK Inhibitors
Dr Yashpal Manchanda, New Delhi,  21 January 2019
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Janus kinase inhibitors also known as jakinibs, inhibit the kinase component of JAKs, thereby preventing them from phosphorylating and stopping the transduction of intercellular signalling.First-generation jakinibs, which include the drugs tofacitinib and ruxolitinib inhibit multiple JAKs.Second-generation jakinibs are still under investigation and more selective target only one JAK isoform, thereby inhibiting a narrower range of cytokines.The dermatological uses of jakinibs include atopic derma...
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