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Sex-Specific Outcome Disparities with Continuous-Flow Left Ventricular Assist Devices.

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eMediNexus    09 November 2017

The widespread utilization of continuous flow left ventricular assist devices CF LVADs has led to concerns regarding increased adverse effects especially in women. The aim of a new study published in ASAIO Journal was to investigate sex specific outcomes after CF LVADs. Here Medline Embase Scopus and the Cochrane Library databases were searched for publications reporting sex specific outcomes after CF LVADs from January 2008 through January 2017. A total of 10 studies including 4 493 CF LVAD recipients were included in the analysis. The findings showed that the overall rate of stroke was significantly higher in women. This was true for both ischemic and hemorrhagic strokes. Women were also more likely to develop right heart failure HF necessitating right ventricular assist device RVAD implantation. Other adverse events including renal failure bleeding and device related infection were comparable in both genders. Furthermore the overall mortality while on CF LVAD was similar in both groups. The results indicated that women are at greater risk of significant complications such as cerebrovascular events and right HF necessitating RVAD after CF LVAD implantation. Further research were recommended to better understand the mechanisms underlying these sex specific outcome disparities.

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